Publications
Breen Lab publications coming soon!
Prior Work
Breen, M.E.; Joy, S.T.; Baruti, O.J.; Beyersdorf, M.S.; Henley, M.J.; DeSalle, S.N.; Ycas, P.D.; Croskey, A.; Cierpicki, T.; Pomerantz, W.C.K.; Mapp, A.K. Garcinolic Acid Distinguishes Between GACKIX Domains and Modulates Interaction Networks. ChemBioChem, 2023, 24, e202300439.
Joiner, C.M.*; Breen, M.E.*; Mapp, A.K. Electron-deficient p-benzoyl-L-phenylalanine derivatives increase covalent chemical capture yields for protein-protein interactions. Protein Science, 2019, 28, 1163-1170.
*Authors contributed equally to this work
Kersten, K.M; Breen, M.E.; Mapp, A.K.; Matzger, A.J. Pharmaceutical Solvate Formation for the Incorporation of the Antimicrobial Agent Hydrogen Peroxide. Chemical Communications, 2018, 54, 9286-9289.
Breen, M.E.; Mapp, A.K. Modulating the masters: chemical tools to dissect CBP and p300 function. Current Opinion in Chemical Biology, 2018, 45, 195-203.
Joiner, C.M.*; Breen, M.E.*, Clayton, J.; Mapp, A.K. A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of In Vivo Protein-Protein Interactions. ChemBioChem, 2017, 18, 181-184.
*Authors contributed equally to this work
Brandvold, K.B.; Santos, S.M.; Breen, M.E.; Lachacz, E.J.; Steffey, M.E.; Soellner, M.B. Exquisitely Specific Bisubstrate Inhibitors of c-Src Kinase. ACS Chemical Biology, 2015, 10, 1387-1391.
Breen, M.E.; Soellner, M.B. Small Molecule Substrate Phosphorylation Site Inhibitors of Protein Kinases: Approaches and Challenges. ACS Chemical Biology, 2015, 10, 175-189.
Breen, M.E.; Steffey, M.E.; Lachacz, E.J.; Kwarcinski, F.E.; Fox, C.C.; Soellner, M.B. Substrate Activity Screening with Kinases: Discovery of Small-Molecule Substrate-Competitive c-Src Inhibitors. Angewandte Chemie International Edition 2014, 53, 7010-7013.
Yestrepsky, B.D.; Xu, Y.; Breen, M.E.; Li, X.; Rajeswaran, W.G.; Ryu, J.G.; Sorenson, R.J.; Tsume, Y.; Wilson, M.W.; Zhang, W.; Sun, D.; Sun, H.; Larsen, S.D. Novel Inhibitors of Bacterial Virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the Inhibition of Group A Streptococcal Streptokinase Expression. Bioorganic & Medicinal Chemistry 2013, 21, 1880-1897.
Grove, R.C.; Malehorn, S.H.; Breen, M.E.; Wheeler, K.A. A Photoreactive Crystalline Quasiracemate. Chemical Communications 2010, 46, 7322-7324.
Talukdar, A.; Breen, M.; Bacher, A.; Illarionov, B.; Fischer, M.; Georg, G.; Ye, Q.; Cushman, M. Discovery and Development of a Small Molecule Library with Lumazine Synthase Inhibitory Activity. Journal of Organic Chemistry 2009, 74, 5123-5134.
Breen, M.E.; Tameze, S.L.; Dougherty, W.G.; Kassel, W.S.; Wheeler, K.A. Structural Studies of Enantiomers, Racemates, and Quasiracemates. 2-(3-Bromophenoxy)-propionic Acid and 2-(3-Methoxy-phenoxy)propionic Acid. Crystal Growth & Design 2008, 8, 3863-3870.